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seeandreade4 - Nitric Oxide in the Nervous System
یکشنبه 20 شهریور 1390  02:37 ق.ظ
توسط: Tomas Andrews

Nitric Oxide in the Nervous System




Author: Peter Jenner, Stephen R. Vincent
Type: eBook
Date Released: 1995
Format: pdf
Language: English
Page Count: 333
Isbn10 Code: 0127219854
Isbn13 Code: 9780127219851


The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscientists to invoke NO to explain many previously unexplained phenomena in neurobiology. Fortunately, the development of numerous pharmacological agents is now allowing thesehypotheses to be tested.This volume will provide a synopsis of what is now known about NO. How and where NO is produced, how it acts at the molecular level to activate the synthesis of cGMP, and the possible targets of cGMP in the nervous system are reviewed. The roles of theNO/cGMP signal transduction pathway in the central and peripheral nervous systems, in glial cells, and in neuropathology are then explored. Together, these reviews will lead to further work explaining the varied functions of NO. Key Features* Describes how and why NO is produced in the nervous system* Examines all that is known of NOs role as a neurotransmitter* Explores cellular actions and physiological roles in the brain and peripheral nervous systemCovers NOs molecular synthesis to its role in neuropathology From the Back Cover Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological, and therapeutic aspects of chosen research areas.The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way of thinking about neurotransmission. These special properties have also lead neuroscientists to invoke NO to explain many previously unexplained phenomena in neurobiology. Fortunately, the development of numerous pharmacological agents is now allowing these hypotheses to be tested.It is hoped that this volume will provide a synopsis of what we now know about NO. How and where NO is produced, how it acts at the molecular level to activate the synthesis of cGMP, and the possible targets of cGMP in the nervous system are reviewed. The roles of the NO/cGMP signal transduction pathway in the central and peripheral nervous systems, in glial cells and in neuropathology are then explored. Together, these reviews should lead to further work elucidating the varied functions of that most fugacious of neurotransmitters, NO.

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